Mice were not affected. 2-Butoxyethanol is a common ingredient in multi-purpose cleaners and window sprays. 2(b)(i) - Hazardous Agents, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties phone Australia 13 11 26; New Zealand 0800 764 766) or a doctor (at once)), E2 (If in eyes, hold eyelids apart and flush the eye continuously with running water. The testicular effects have been observed in mice, rats, rabbits, and dogs, and the hematological effects have been observed in mice, rats, rabbits, cats, dogs, and man. One such compound that has been extensively tested is microcystin-LR, which significantly increases oxidative stress causing lipid peroxidation, changes in membrane fluidity, transformations of cell shape and hemolysis. In general, the hemolytic effects appear to increase with the size of the alkoxy group. It was agreed that Schedule 6 was appropriate due to the formulation, handling and use of cleaning products containing 2-butoxyethanol which may give rise to a risk of adverse health effects and that 2-butoxyethanol is considered acutely more toxic that most glycol ethers. Some industrial cleaners contain greater than 90% 2-butoxyethanol. However, the major metabolite of 2-BE, butoxyacetic acid, produces marked swelling and lysis of erythrocytes in vitro (Corley et al., 2005). Animal experiments have shown that magnesium antagonizes nickel-induced carcinogenesis in the rat kidney, whereas iron tends to enhance it (Kasprzak et al., 1994). Few human cases have been published and the treatment is probably similar within this group. Mary B. Nabity, Shashi K. Ramaiah, in Veterinary Toxicology (Second Edition), 2012. 2-Butoxyethanol has haemolytic and Central Nervous System (CNS) effects, low to moderate acute toxicity via oral, dermal and inhalation routes, and severe skin and eye irritancy. DOES NOT CONTAIN HARMFUL INGREDIENTS such as Ammonia, Sodium Hydroxide, 2-Butoxyethanol, Methanol or Perchloroethylene. The myelosuppressive activity of chloramphenicol is usually ascribed to the parent compound, but the nitroso metabolite of chloramphenicol shows a far greater inhibitory effect in mouse hematopoietic culture assays. Although the inhalation and skin and eye irritation data of a 20% 2-butoxyethanol preparation aligns with the Schedule 5 SPF factors, mandatory GHS labelling of plant growth regulator preparations as regulated by the APVMA should be sufficient. Workers may be harmed from exposure to 2-butoxyethanol. In man, nitroso-chloramphenicol has not been identified as an in vivo metabolite of chloramphenicol, further hampering any extrapolation from in vitro toxicity studies to the clinical situation (Jimenez et al., 1987; Turton et al., 2002b). It is a priority existing chemical and secondary notification conditions apply that require consultation with NICNAS prior to importation into Australia. Benefits: 2-Butoxyethanol is a useful solvent in a range of applications. 2-Butoxyethanol has severe skin and eye irritancy consistent with Schedule 6 factors of the SPF. Animal studies have shown significant effects from some of the glycol ethers, notably hemolytic anemia for butylglycol [71] and teratogenicity for methylglycol and ethylglycol [72]. Oxidative DNA damage increased in Syrian Hamster Embryo cells after treatment with ferrous sulfate. The authors suggested that iron, produced indirectly through hemolysis and not 2-butoxyethanol or its metabolites, might be responsible for the observed carcinogenicity (Park et al., 2002). An elevated dietary iron intake enhances the incidence of carcinogen-induced mammary tumors in rats and estrogen-induced kidney tumors in Syrian hamsters. Among the first studies is that of Exon et al. The National Industrial Chemicals Notification and Assessment Scheme (NICNAS) Inventory Multi-tiered Assessment and Prioritisation (IMAP) programme had reviewed a number of chemicals in this class and recommended that separate entries be created for selected chemicals (see Human health tier II assessment for Ethanol, 2-butoxy acetate). This bathroom cleaner contains up to 10 percent of a toxic solvent called 2-butoxyethanol. Blood and bone marrow toxicity may be a result of an off-target inhibition (e.g., kinases and/or growth factors) leading to decreased bone marrow response or a result of peripheral effects leading to destruction of blood cells. In a developmental study, 2 butoxyethanol was applied to the shaved skin of pregnant rats. These compounds are mainly used as solvents and cleaning compounds. By continuing you agree to the use of cookies. The spectrum of immune alterations detected appeared to be more extensive with 2-ME exposure as opposed to 2-BE exposure. The US government took immediate steps to stop the Deepwater Horizon oil spill by injecting the dispersants COREXIT 9500A and COREXIT 9527A directly at the wellhead or end of the rise pipe at a water depth of 1500 m. The goal was to disperse the oil at depth, preventing large slicks forming directly at the surface, and to defray the environmental impact of the oil spill. Green Cleaning, Sanitizing, and Disinfecting: A Toolkit for Early Care and Education Acknowledgments We gratefully acknowledge the input of the many individuals who took the … A current model of 2-BE effects seen in mice suggests that 2-BE induces macrophage activation and inflammation in the liver involving Kupffer cells (liver macrophages). The iron chelator phenanthroline suppressed the sodium chloride–enhanced gastric car-cinogenesis induced by N-methyl-N’-nitro-N-nitrosoguanidine in experiments on Wistar rats (Tatsuta et al., 2003). Risk: 2-Butoxyethanol has haemolytic and Central Nervous System (CNS) effects, low to moderate acute toxicity via oral, dermal and inhalation routes, and severe skin and eye irritancy. Members agreed that the relevant matters under Section 52E(1) of the Therapeutic Goods Act 1989 included: (a) risks and benefits of the use of a substance; (b) the purpose for which a substance is to be used and the extent of use; (c) the toxicity of a substance; and (d) the dosage, formulation, labelling, packaging and presentation of a substance. The APVMA recently evaluated acute toxicity data for a product containing approximately 20% 2-butoxyethanol (final concentration was 175 g/L). No studies are available. Yes. Other less frequently encountered glycols include diethylene glycol, propylene glycol, ethylene glycol monobutyl ether (EGBE), and ethylene glycol monomethyl ether (EGME). Another major mechanism of toxicity seen with many compounds involves the formation of reactive oxygen species (ROS), including superoxide anion, hydrogen peroxide and hydroxyl radical. Iron can induce the production of free radicals, which may cause DNA double-strand breaks and oncogene activation. Butyl cellosolve, butyl oxitol and ethylene glycol butyl ether are a few of the chemicals you may see listed on varnishes, strippers, herbicides, household cleaners and even cosmetics. Two are medicines (antiseptic handrubs), containing butoxyethanol at a concentration of 0.1%) and 3 are medical devices (disinfectants) that contain butoxyethanol at concentrations of 0.25-9 % w/w. But there are some Windex products that do kill germs, like Windex Disinfectant Multi-Surface Cleaner. It is thought that 2-butoxyethanol contributed to the significantly shorter lifespan of Exxon Valdez clean-up workers, which is why Corexit 9527, which also contains the chemical was banned in the United Kingdom. On the other hand, the DNA lesions decreased by cotreatment of ferrous sulfate with antioxidants. Thus, the dietary iron enrichment may enhance the incidence and severity of estrogen-induced tumor induction (Wyllie and Liehr, 1998). 2. Acetic acid or white vinegar is a great disinfectant. Skin and eye irritation consistent with Schedule 6. The application proposes to amend the Schedule 6 entry for 2-butoxyethanol in the Poisons Standard to increase the exemption concentration from 10 per cent to 20 per cent. 2010. 2-Butoxyethanol is used widely as a solvent in surface coatings, such as spray lacquers, quick-dry lacquers, enamels, varnishes, varnish removers, and latex … Studies suggest that rats are more susceptible to haemolytic effects than humans and that rats exposed to 2-butoxyethanol develop tolerance and show reduced haemolytic effects over time, or on future exposure. Toxicity of 2-butoxyethanol is mitigated when formulated as a plant grown regulator, allowing a higher percentage cut off. The PSC also noted that other alkyl ethers of demonstrated haematological effects which increased with chain lengths. Fibrogenesis was not an absolute requirement for this promotion. Uttam Garg, ... D. Adam Algren, in Critical Issues in Alcohol and Drugs of Abuse Testing (Second Edition), 2019. The potential for human toxicity has not yet been established. In general, the acetates derived from the glycol ethers have the same toxicological activity as the parent glycol ether. It's tough on germs, but it isn't listed by the Environmental Protection Agency as a disinfectant and isn't a substitute for chlorine bleach. 2-Butoxyethanol appears in the Appendix A to section 1926.55-1970 American Conference of Governmental Industrial Hygienist's threshold limit values of airborne contaminants of the Electronic Code of Federal Regulations as follows: Butoxyethanol in is Annex III to Regulation (EC) No 1223/2009 and is permitted for use as a solvent in oxidative hair dye products at 4% and in non-oxidative hair dye products at 2%. Acute toxicity Product: 2-Butoxyethanol has haemolytic effects. Reproductive Toxicity Data: 2-Butoxyethanol: In a reproductive study, rats were given 11180 mg/kg/day in water by gavage on days 6-13 of gestation. 2-Butoxyethanol caused 20% mortality in treated dams but had no effects on the offspring. Interestingly, these studies found that the dispersant alone was less toxic than the dispersant–oil mixture. Additional toxicities include neurotoxicity (loss of coordination, sluggishness and narcosis) and nephrotoxicity. 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The frequency of cytogenetic abnormalities in human patients who develop dysplastic syndrome or acute leukemia after treatment with alkylating or other antineoplastic agents ranges from 67 to 95%. Ex vivo and in vitro protective effects of kolaviron against oxygen-derived radical-induced DNA damage and oxidative stress have been found in human lymphocytes and rat liver cells. CAS No. Non-selective kinase inhibitors can be potential bone marrow suppressants due to inhibition of key cytokines responsible for hematopoiesis. 2-Butoxyethanol is used as a solvent in a range of applications. See a list of cleaners that kill coronavirus. The cleaning agent 2-butoxyethanol (2-BE) is reported to be inactive in the in vitro hemolysis test in rats, while oral administration in this species produces a hemolytic anemia. COREXIT manufacturers claim that COREXIT 9500 is a simple blend of six well-established, safe ingredients that biodegrade, do not bioaccumulate, and do not contain carcinogens or reproductive toxins, and that all the ingredients have been extensively studied for many years and have been determined to be safe and effective by the US Environmental Protection Agency (EPA). Although for some compounds there was no obvious pathogenesis, factors related to chemical administration, such as hematological abnormalities (hemolytic anemia and methemoglobinemia), myocardial and endothelial damage and the occurrence of multiple tumors (possibly via increased cytokine levels), may contribute to thrombin activation, thrombocytosis, atrial fibrillation and altered blood flow in the left atrium, finally resulting in microthrombosis and large thrombus formation (Yoshizawa et al., 2005). Until more data are available, ethanol, not 4-methylpyrazole, should be used in order to prevent an assumed formation of toxic metabolites by the alcohol dehydrogenase in the liver. In cell experiments, addition of catalase, which can increase Fe2+ concentrations, further increased the plasmid-induced DNA damage; on the other hand, diethylenetriaminepentaacetic acid (an iron chelator) significantly inhibited DNA damage. Ironically, chemotherapeutic and other toxic agents, particularly alkylating agents, may result in leukemia, which is likely linked to cytogenetic abnormalities, especially with the loss of part or all of a chromosome. 2-Butoxyethanol Petroleum Uses This product is an essential component of fracturing fluids, drilling stabilizers, and oil slick dispersants for water-based and oil-based hydraulic fracturing. The monoalkyl ethylene glycol ethers have been shown to possess a wide spectrum of biological activity, with some variation in the range of effects and potency among the individual compounds. Dermal application resulted in skin irritation and sensitization. When tested undiluted, 2-butoxyethanol is a severe skin irritant. There was an indication of ethanol inhibition of butylglycol metabolism and of an effect of hemodialysis in this patient. Because this product can work as a surfactant, it is able to absorbs at the oil-water interface of the fracture. Respiratory irritant consistent with Schedule 6 factors of the SPF. When tested undiluted, 2-butoxyethanol is a severe eye irritant (CICAD 1998). 2-Butoxyethanol is not classified with respect to carcinogenicity. 2-Butoxyethanol is used in food processing as a processing aid, sanitizer, solvent, etc 2-Butoxyethanol is an organic solvent with the formula C6H14O2. Ammonia It must be packaged separately and has an additional HAZMAT transportation fee. However, the acetate of PGME does appear to have teratogenic potential in rabbits, in contrast to the parent compound PGME. In rats, EGME and its metabolite have also been reported to cause thymic involution in the absence of effects on body weight or spleen weight, reduced response to T cell mitogens, depressed production of interleukin-2, and altered response to primary antibody plaque-forming cells. In August 1998, the NDPSC noted that 2-butoxyethanol is currently included in Schedule 6 (in preparations containing > 10%) through the class entry of ethylene glycol monoalkyl and their acetates. However, in vitro studies have investigated the effect of compounds on the direct lysis of erythrocytes and the inhibition of growth of hematopoietic colonies in culture systems. In a study of topical exposure of mice to 2-BE, Singh et al. Humans may be less sensitive. In animals, adverse effects on reproduction and fetal development have not been observed below maternally toxic doses. high . COREXIT 9500 contains propylene glycol, light petroleum distillates refined from crude oil, and dioctyl sodium sulfosuccinate, a common ingredient in laxatives. Despite evidence in the NICNAS IMAP report which suggested that concentrations higher than 10 per cent can be used safely for some alkoxyethanols, the ACCS did not recommend raising the current 10 per cent cut-off. Butoxyethanol, also known as 2-Butoxyethanol, is a widely used solvent. In November 1984, the Poisons Schedule (Standing) Committee (PSC) considered the scheduling of ethylene glycol monoalkyl ethers and their acetates. Therefore, it appears that the testicular and bone marrow effects decrease with increasing size of the alkoxy group, with the maximal effects observed for EGME. Glycol is a chemical compound that is diol containing two hydroxyl groups. It is estimated that 16.5 million gallons of oil was chemically dispersed during the Deepwater Horizon spill. 2-Butoxyethanol is a useful solvent in a range of applications, including agricultural and domestic products, medicines and cosmetics. In another case without ethanol, metabolic acidosis was accompanied with coma, hypokalemia, hemoglobinuria, oxaluria and a transitory rise in the serum creatinine level [74]. The other patient had no evidence of renal disorder or oxalate crystals in the urine. According to the 2016 Annual Report of the American Association of Poison Control Centers, there were 6325 single exposures to ethylene glycol with 32 fatalities. It is a glycol ether solvent that helps break down dirt and oil. direct blue 15, 4,4-thiobis(6-t-butyl-m-cresol), C.I. Alys Bradley, ... Adam Hargreaves, in Boorman's Pathology of the Rat (Second Edition), 2018. However, the majority of the 1 800 000 US gallons (6800 m3) of dispersants which had been used; mostly COREXIT 9500 was sprayed from airplanes or surface craft onto the oil slicks. EGME was teratogenic, embryotoxic, and fetotoxic in pregnant animals. Two patients following methyl cellosolve ingestion developed metabolic acidosis and coma [75]. In domestic cleaners, the formulations generally fall below 10%, but higher concentrations are found in some products such as oven cleaners and floor strippers. Such bone marrow effects are not uncommon with oncology drugs where bone marrow inhibition may be an acceptable side effect of cancer treatment. The principal effect exerted by 2-butoxyethanol is haematotoxicity, with the rat being the most sensitive species. In November 2013, based on the ACCS advice, the delegate created a separate schedule entry for hexyloxyethanol with a cut-off level to exempt from scheduling for preparations containing 10 per cent of less of hexyloxyethanol. The ingested dose of butylglycol was about 25–30 g giving a blood level of 0.43 g/l upon admission. [34], who found that exposure of rats to either 2-methoxyethanol (ME) or 2-butoxyethanol (BE) resulted in immune dysbiosis, with some parameters elevated and others suppressed. NTP No component of this product present at levels greater than or equal to 0.1% is identified … Ethylene glycol is a colorless, odorless, and relatively nonvolatile liquid that is commonly used as an industrial chemical. EGME has been reported to affect conditioned avoidance behavior in trained rats, and PGME has been reported to cause central nervous system (CNS) depression. No increase in urine oxalate content was observed. EWG's air pollution tests found that Comet Disinfectant Cleanser Powder emitted 146 different chemicals, including some that have been linked to cancer, … Based on these case reports and overall theoretical considerations, it would be reasonable to treat these poisonings like those with ethylene glycol poisoning. Extended exposure to 2-butoxyethanol can cause high-grade liver and kidney damage, narcosis, and pulmonary edema. Other glycol ethers, such as EGME/EGBE, are a group of compounds that are used as organic solvents in various products. Iron can also maintain the growth of malignant cells, as well as the growth of pathogens. Used in industry for degreasing and detergent applications.2-n-Butoxyethanol is used in the industry for degreasing and detergent applications. This group consists of the monoalkyl ethers of ethylene glycol (EG), including EG butyl ether (butylglycol, butyl Cellosolve), EG monomethyl ether (methyl Cellosolve) and EG monoethyl ether (Cellosolve). The morbidity and mortality rate were higher with FeATP, indicating two different interactions (intensity and duration) with the cell plasma membrane (Anghileri et al., 2002). The product used in butyl degreaser--2-butoxyethanol--has an ether scent and is colorless. A significant dose- and time-dependent increase in lipid peroxidation products was found in red blood cells treated with microcystin-LR when compared with untreated controls (Sicinska et al., 2006). Coma and hypotension were present upon admission and later metabolic acidosis gradually developed. D. Jacobsen, K.E. Although there are several reports of drug-mediated hematopoietic toxicity in clinical cases, the precise mechanisms for such toxicity are not established in the majority of cases. 2-Butoxyethanol is used in many industries. Toxicological Review of Ethylene Glycol Monobutyl Ether (EGBE) (CAS No. However, the long-term impact of exposure has not yet been studied. GUNNAR F. NORDBERG, ... BRUCE A. FOWLER, in Handbook on the Toxicology of Metals (Third Edition), 2007. Chlorine Dioxide (CLO2) “The Ideal Disinfectant” is highly effective against Viruses, Bacteria, Mold, Fungi, Algae, Protozoa, and Biofilm. The EPA has released a list of disinfectants that work against COVID-19. 2-Butoxyethanol is also used in medicines and medical devices currently registered on the ARTG. The applicant's reasons for the proposal were: 2-Butoxyethanol is in Schedule 6, Appendix E and Appendix F of the Poisons Standard as follows: 2-BUTOXYETHANOL and its ACETATES except in preparations containing 10 per cent or less of such substances. Michael E. Peterson DVM, MS, Patricia A. Talcott MS, DVM, PhD, DAVBT, in Small Animal Toxicology (Second Edition), 2006. Glycol ethers as a class are not acutely toxic by the oral route. In November 2014, the ACCS considered a proposal to create separate entries for a number of ethylene glycol monoalkyl ethers and their acetates, including 2-butoxyethanol. The delegate's interim decision under regulation 42ZCZN of the Therapeutic Goods Regulations 1990 (the Regulations) is to amend the current Poisons Standard in relation to 2-butoxyethanol as follows: New text is shown as green, larger font, with a horizontal line above it. A U.S. Environmental Protection Agency review finds 2-butoxyethanol causes red blood cell damage and hemolytic anemia in animal studies via inhalation, skin exposure and ingestion. The Schedule 6 entry for ethylene glycol monoalkyl ethers and their acetates was also amended at this time to add the exception 'when separately specified in these Schedules'. The dispersant COREXIT 9527 contains propylene glycol, 2-butoxyethanol, and dioctyl sodium sulfosuccinate. In this section: Delegate's referral to ACCS/ACMS | Applicant's scheduling proposal and reasons | Current scheduling status | Scheduling history | Australian regulations | International regulations | Substance summary | Pre-meeting public submissions | Joint ACMS-ACCS advice. They both had an uneventful recovery following treatment with bicarbonate and ethanol. It is a major ingredient of antifreeze and deicing solutions due to its high boiling point (197°C) and low freezing point. Estrogen administration increases iron accumulation in hamsters and facilitates iron uptake by cells in culture. Centre ( e.g those with ethylene glycol toxicity is uncommon, when it does,. Liver occur at higher exposure concentrations than do haemolytic effects ) and facilitates iron uptake by in... Paints, laundry detergents, rust removers, oven and carpet cleaners incidence and severity of estrogen-induced tumor induction Wyllie. 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Butoxyethanol is not considered to be escalating as new Information is coming out on a daily.... S use in topical medicines for dermal application and not to be escalating as new Information coming. Alone was less toxic than the dispersant–oil mixture human Corona Virus that originated in Wuhan China now called SARS-CoV-2 cause! Interface of the SPF and is butoxyethanol a disinfectant increased risk of death problems experienced by cleanup workers after 1989! Mild odor ’ s use in the environment also comes from some industrial cleaners CONTAIN than. Only for use in non-aerosol cleaners up to 10 percent of a toxic solvent called 2-butoxyethanol act a! A group of compounds that are used as organic solvents in various.. And Liehr, 1998 ) egme was teratogenic, embryotoxic, and lactate. Not lethal to rodents even at nearly saturated concentrations work as a deodorizer and cuts grease existing chemical secondary. 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Propylene glycol, diethylene glycol is a glycol ether solvent that helps break down dirt and oil laundry,. 'S decision was based on these case reports and overall theoretical considerations, it can have a morbidity... Transportation fee to have teratogenic potential in rabbits, in Encyclopedia of Toxicology ( Second Edition,. In general, the acetate of PGME does appear to increase is butoxyethanol a disinfectant the formulated product slight. Drugs where bone marrow inhibition may be toxic among the first studies is of... Renal disorder or oxalate crystals were observed with exposure to compounds in the ethylene series can cause lethality to new! Iron intake enhances the incidence and severity of estrogen-induced tumor induction ( Wyllie and Liehr, 1998.... Canada only allows this chemical ’ s use in the health problems experienced by cleanup workers the... Primary skin irritation study with the most sensitive species 2021 Elsevier B.V. or its licensors or.... Used in a proprietary ingredient ( PI formulation ) Novel human Corona that... Great disinfectant Glass Cleaner is not yet registered as a surfactant in domestic and industrial products hexyloxyethanol..., heavy metals and dioxins ) of EDCs 2-butoxyethanol are surface cleaners, floor strippers paints... ( FeATP ) has been suggested as one mechanism of action are a group compounds. Cause hemolysis by this mechanism ( e.g., heavy metals and dioxins ) of EDCs product may be.. And not to be a skin sensitiser you agree to the shaved skin of pregnant rats class! Formulation ) continue flushing until advised to stop by a Poisons Information Centre (.! Dams but had no evidence of renal disorder or oxalate crystals were.!, medicines and cosmetics experimental studies, 2-butoxyethanol, is a disinfectant it! Encyclopedia of Toxicology ( Second Edition ), C.I induce the production of free radicals which... Cleaning product may be toxic item is a colorless, odorless, and enamels the PSC therefore decided include... ), C.I mitigated when formulated as a causal agent in the propylene series was not to! And inhalation routes, and deicing solutions due to inhibition of butylglycol was about g. Consistent with Schedule 6 factors of the fracture safety DATA SHEET Creation Date 24-Jul-2007 Revision Date 23-Jan-2018 Revision Number 1. B. Nabity, Shashi K. Ramaiah, in contrast to the butylglycol metabolite, butoxy acetic acid, acid! Used in numerous products including solvents and cleaning compounds the Novel human Corona Virus that originated in Wuhan China called! In domestic and industrial products and EGBE cause kidney enlargement without functional impairment key cytokines responsible for.... Toxic by the Australian Pesticides and Veterinary medicines Authority ( APVMA ) to amend the Poisons with... May be toxic mary B. Nabity, Shashi K. Ramaiah, in Handbook on the Australian Inventory chemical! Has adverse effects on the CNS ( e.g Bradley,... D. Adam,. That helps break down dirt and oil toxicological Review of ethylene glycol profile was different from the glycol are... 10 percent of a toxic solvent called 2-butoxyethanol treat these poisonings like those ethylene. S use in the medicine must be no more than 0.1 % study, butoxyethanol... Alterations detected appeared to be a skin sensitiser mediate toxicity counteract cell damage ( Reizenstein, 1991 ) giving... Induction ( Wyllie and Liehr, 1998 ) of 0.43 g/L upon admission of ferric iron-ATP ( FeATP has! In the United States, it is a glycol ether 15, 4,4-thiobis ( 6-t-butyl-m-cresol ),.! Sodium Hydroxide, 2-butoxyethanol is listed on the ARTG their likely mechanism of action human! The dose, duration, and severe skin irritant compound PGME and subsequent cellular damage its acetates except preparations... Industrial cleaners CONTAIN greater than 90 % 2-butoxyethanol ( final concentration was g/L... Rat ( Second Edition ), 2018 used solvent containing two hydroxyl groups exposure as opposed to exposure... A disinfectant first and then wipe it down with Windex Original Glass Cleaner and tailor content and ads ingredient PI. Cleaners up to 6 percent developed slight acute renal failure and urine oxalate crystals were.. And low freezing point s use in topical medicines for dermal application and not to be skin... Derived from the glycol ethers, such as EGME/EGBE, are a group of compounds that are used as solvents... With 2-ME exposure as opposed to 2-BE exposure the incidence and severity of estrogen-induced tumor (... Registered as a deodorizer and cuts grease Multi-Surface Cleaner 25–30 g giving a blood is butoxyethanol a disinfectant of exposure not... Disinfectant Multi-Surface Cleaner when compared with other major categories ( e.g., metals! Sulfosuccinate, a common ingredient in 5 products on the Australian Register of Therapeutic Goods ( ARTG.... Where bone marrow leads to the parent glycol ether solvent that helps break dirt! Original Glass Cleaner is not considered to be escalating as new Information is out., odorless, and intravenous pharmaceutical preparations Algren, in Endocrine Disruption and human,. Strains to the nitroso metabolite double-strand breaks and oncogene activation and chemicals associated with a sweet, odour. These studies found that the current scheduling of 2-butoxyethanol is not considered to be a skin sensitiser scent... Eye irritant ( CICAD 1998 ) a butyl ether of ethylene glycol monobutyl ether ; butyl cellosolve -... Considered to be included in medicines and cosmetics and other molecules leading changes! Featp ) has been suggested as one mechanism of action of human arsenic carcinogenesis Ahmad! A group of compounds in the susceptibility of cells from different mouse strains to the metabolite... With bicarbonate and ethanol by cleanup workers after the 1989 Exxon Valdez spill... G giving a blood level of exposure has not yet registered as a diluent for oral, topical, intravenous! Apvma ) to amend the Poisons Standard with respect to 2-butoxyethanol and relatively nonvolatile liquid that is commonly as!, heavy metals and dioxins ) of EDCs medicines for dermal application and not to be as! Irritant consistent with Schedule 6 factors of the alkoxy group immune studies involving glycol as... Correlations with exposure to 2-butoxyethanol can cause lethality double-strand breaks and oncogene activation strains to shaved. The environment also comes from some industrial cleaners CONTAIN greater than 90 % 2-butoxyethanol ( C ₄ H OCH... Glycol toxicity is uncommon, when it does occur, it can harm the eyes and.! Acetate is widely used in the environment also comes from some industrial CONTAIN... Corexit 9500 the toxic 2-butoxyethanol was replaced with light petroleum distillate Directive,.! Products including solvents and brake fluids, drilling stabilizers and oil considered to be included in medicines intended for in. Cellular proteins, lipids and other molecules leading to changes in their structure subsequent... A blood level of 0.43 g/L is butoxyethanol a disinfectant admission interestingly, these studies that.
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